Comamonas testosteroni

General Information

Comamonas testosteroni is a fascinating microorganism that has garnered significant interest in various fields of research due to its unique metabolic capabilities and environmental adaptability. This bacterium is particularly notable for its ability to degrade a wide range of organic compounds, including aromatic hydrocarbons, which makes it a valuable agent in bioremediation efforts. One of the most remarkable features of C. testosteroni is its capacity to metabolize testosterone and other steroids, a trait that is relatively rare among bacteria. This ability is not only intriguing from a biochemical perspective but also has potential applications in the pharmaceutical industry for the biotransformation of steroidal drugs. Another key characteristic of Comamonas testosteroni is its versatility in utilizing various carbon sources, which allows it to thrive in diverse environments, from soil and water to industrial waste sites. This adaptability is underpinned by a complex and efficient enzymatic system that enables the bacterium to break down complex organic molecules into simpler compounds that it can use for growth and energy. In addition to its environmental and industrial applications, C. testosteroni has also been studied for its role in the human microbiome, particularly in the gut, where it may contribute to the metabolism of dietary components and xenobiotics. The bacterium's genetic and metabolic pathways have been extensively characterized, providing valuable insights into microbial ecology and the potential for engineering C. testosteroni for specific biotechnological applications. Overall, Comamonas testosteroni stands out as a model organism for studying microbial degradation of pollutants, steroid metabolism, and environmental adaptability, making it a subject of ongoing research with promising implications for environmental science, medicine, and biotechnology.

Comamonas testosteroni is a fascinating bacterium known for its unique ability to degrade a variety of aromatic compounds, including testosterone. This metabolic capability makes it particularly valuable in bioremediation efforts, as it can help in the detoxification of environments contaminated with steroid hormones and other pollutants. The organism is part of the Comamonadaceae family and is often found in soil and water environments, where it plays a crucial role in the carbon cycle. One of the most interesting aspects of C. testosteroni is its capacity to utilize testosterone as a sole carbon source, which is relatively rare among bacteria. This ability not only highlights its metabolic versatility but also positions it as a model organism for studying steroid degradation pathways. Researchers have been able to identify specific enzymes involved in this process, such as hydroxysteroid dehydrogenases, which are essential for the breakdown of steroid compounds. Furthermore, C. testosteroni has been studied for its potential applications in biotechnology, particularly in the development of biocatalysts for the synthesis of steroid derivatives. Its unique enzymatic pathways could lead to innovative methods for producing pharmaceuticals and other valuable chemicals. The organism's genome has been sequenced, providing insights into its metabolic capabilities and genetic adaptations, which can inform future research in environmental microbiology and synthetic biology. In summary, Comamonas testosteroni stands out due to its specialized metabolic functions, ecological significance, and potential applications in bioremediation and biotechnology, making it a subject of ongoing scientific interest.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Betaproteobacteria

Order: Burkholderiales

Family: Comamonadaceae

Genus: Comamonas

Species: Comamonas testosteroni

NCBI ID

285

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/034/479/025/GCF_034479025.1_ASM3447902v1

File for sequence-based predictions:
GCF_034479025.1_ASM3447902v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Comamonas testosteroni is a Gram-negative, rod-shaped organism that has garnered attention due to its potential clinical implications. It is primarily known for its role in the degradation of various environmental pollutants, but its interactions with human health are noteworthy. While C. testosteroni is not a common human pathogen, it has been associated with infections in immunocompromised patients, particularly in cases of bacteremia and wound infections. Clinical relevance arises from its ability to utilize testosterone and other steroid compounds, which may influence its pathogenicity and survival in human hosts. One of the significant concerns regarding C. testosteroni is its potential for antimicrobial resistance. It has been documented to possess resistance mechanisms against multiple classes of antibiotics, which complicates treatment options for infections it may cause. This resistance is often attributed to the presence of plasmids that carry resistance genes, making it a subject of interest in studies focused on antibiotic resistance in environmental and clinical settings. In terms of immune evasion, C. testosteroni can produce biofilms, which enhance its survival in hostile environments, including the human body. Biofilm formation is a critical factor in the persistence of infections, as it protects the bacteria from both the host's immune response and antibiotic treatment. While there are no widely recognized medical applications of C. testosteroni in terms of probiotics or vaccines, its metabolic capabilities are being explored for bioremediation purposes. Understanding its interactions with human health and its environmental roles may provide insights into managing infections and developing new therapeutic strategies. Overall, the clinical implications of Comamonas testosteroni highlight the need for continued research into its pathogenic potential and resistance mechanisms.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Comamonas testosteroni is a versatile bacterium commonly found in various habitats associated with organic matter decomposition and nutrient cycling. This microorganism thrives in environments rich in organic pollutants, particularly in soil and aquatic ecosystems where it plays a crucial role in the biodegradation of aromatic compounds, including those found in petroleum and other industrial wastes. Its ability to utilize a wide range of carbon sources makes it an important player in the microbial community responsible for the breakdown of complex organic materials. Soil Biomes: In terrestrial ecosystems, _C. testosteroni is often isolated from contaminated soils where it contributes to the remediation processes by degrading toxic compounds. Its presence in these environments not only aids in detoxifying the soil but also enhances soil fertility through the recycling of nutrients. Aquatic Biomes: In freshwater and marine environments, _C. testosteroni can be found in sediments and water columns, where it interacts with other microorganisms in the biofilm communities. Here, it participates in the degradation of organic pollutants, thus playing a significant role in maintaining the health of aquatic ecosystems. The ecological interactions of _C. testosteroni extend to symbiotic relationships with plants and other microorganisms, where it may enhance plant growth by improving nutrient availability. Its adaptability to various environmental conditions, including varying levels of oxygen and pH, underscores its ecological significance in both natural and anthropogenically influenced biomes.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The bacterium Comamonas testosteroni is recognized for its diverse industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This microorganism is known for its ability to degrade a variety of organic compounds, making it a valuable asset in biodegradation processes. For instance, C. testosteroni can effectively break down aromatic hydrocarbons, which are common pollutants in industrial waste, thus playing a crucial role in bioremediation efforts aimed at cleaning contaminated environments. In the realm of biofuel production, Comamonas testosteroni has been studied for its potential in the conversion of biomass into biofuels. Its metabolic pathways allow it to utilize various substrates, including fatty acids and alcohols, which can be harnessed in fermentation processes to produce bioethanol and other biofuels. Moreover, this microorganism is also significant in pharmaceutical development due to its enzymatic capabilities. It produces specific enzymes that can be utilized in the synthesis of pharmaceutical compounds, enhancing the efficiency of drug production through enzyme production processes. The ability of C. testosteroni to catalyze reactions under mild conditions makes it an attractive candidate for green chemistry applications. Overall, Comamonas testosteroni demonstrates a multifaceted role in various industries, particularly through its involvement in biodegradation, fermentation, and enzyme production, contributing to sustainable practices and innovative solutions in biotechnology.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro-1.5	google/gemini-flash-1.5	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	mistralai/mistral-7b-instruct	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	aerobic ✓	N/A	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Animal pathogenicity	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	true	true	true	true	true	false	true	false	false	true	true	true	true	true	true	false	false	true	true	true	true	true	true	false	false
Host association	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	gamma	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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