Thomasclavelia spiroformis

General Information

Thomasclavelia spiroformis is a fascinating microorganism that has garnered attention due to its unique morphological and genetic characteristics. This bacterium is part of the family Lachnospiraceae, which is known for its role in the human gut microbiome. One of the most intriguing aspects of T. spiroformis is its spiral shape, which is relatively uncommon among gut bacteria and may have implications for its motility and interaction with the host environment. From a research perspective, T. spiroformis is valuable for several reasons. Firstly, it contributes to the breakdown of complex carbohydrates in the gut, aiding in the production of short-chain fatty acids (SCFAs) such as butyrate. Butyrate is particularly important for colon health, as it serves as an energy source for colonocytes and has anti-inflammatory properties. Additionally, T. spiroformis has been studied for its potential role in modulating the immune system. Its presence in the gut microbiota has been associated with a balanced immune response, which is crucial for preventing inflammatory diseases. Researchers are also interested in its potential probiotic properties, given its ability to outcompete pathogenic bacteria and maintain gut homeostasis. Genomic studies of T. spiroformis have revealed a wealth of information about its metabolic pathways and potential for horizontal gene transfer, which could have implications for antibiotic resistance and the evolution of gut microbiota. The bacterium's genome encodes a variety of enzymes that enable it to utilize a wide range of substrates, making it a versatile and adaptable member of the gut ecosystem. In summary, Thomasclavelia spiroformis is a microorganism of significant interest due to its unique morphology, beneficial metabolic activities, and potential health-promoting properties. Its study not only enhances our understanding of the gut microbiome but also opens up possibilities for therapeutic applications in gut health and disease prevention.

Thomasclavelia spiroformis is a fascinating member of the microbial world, notable for its unique spiral morphology. This organism is part of the phylum Bacteroidetes, which is known for its diverse metabolic capabilities and ecological significance. One of the most interesting aspects of T. spiroformis is its ability to thrive in anaerobic environments, making it a key player in various biogeochemical cycles, particularly in the degradation of complex organic materials in marine and freshwater ecosystems. Unique Morphology: The distinctive spiral shape of T. spiroformis not only sets it apart from other microorganisms but also suggests adaptations that may enhance its survival in specific ecological niches. This morphology can influence its interactions with other microbial communities and its efficiency in nutrient cycling. Metabolic Versatility: T. spiroformis exhibits a remarkable metabolic versatility, allowing it to utilize a range of substrates. This characteristic makes it a valuable organism for studies focused on microbial ecology and the role of bacteria in nutrient cycling. Its ability to break down complex organic compounds can provide insights into the processes that sustain aquatic ecosystems. Research Potential: The unique features of T. spiroformis make it an attractive candidate for research in environmental microbiology and biotechnology. Understanding its metabolic pathways could lead to applications in bioremediation, where it could be harnessed to degrade pollutants in aquatic environments. Additionally, studying its interactions with other microorganisms can shed light on community dynamics and the role of bacteria in ecosystem functioning. In summary, Thomasclavelia spiroformis stands out due to its spiral morphology, metabolic versatility, and potential applications in environmental science, making it a significant organism for further research and exploration.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Erysipelotrichia

Order: Erysipelotrichales

Family: Coprobacillaceae

Genus: Thomasclavelia

Species: Thomasclavelia spiroformis

NCBI ID

29348

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/902/373/765/GCA_902373765.1_MGYG-HGUT-01304

File for sequence-based predictions:
GCA_902373765.1_MGYG-HGUT-01304_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Thomasclavelia spiroformis is a member of the phylum Bacteroidetes and has been identified in various environmental and clinical settings. While specific clinical implications of Thomasclavelia spiroformis are not extensively documented, its presence in the human microbiome suggests potential roles in human health and disease associations. It is important to note that members of the Bacteroidetes phylum are often involved in metabolic processes and can influence immune responses through their interactions with the gut microbiota. Pathogenicity: There is limited evidence directly linking Thomasclavelia spiroformis to specific infections or disease states. However, its close relatives within the Bacteroidetes group are known to be opportunistic pathogens, particularly in immunocompromised individuals. This raises the possibility that Thomasclavelia spiroformis could have similar pathogenic potential under certain conditions. Antimicrobial Resistance: As with many gut-associated bacteria, there is a concern regarding antimicrobial resistance mechanisms that may be present in Thomasclavelia spiroformis. The ability of gut microbiota to acquire and transfer resistance genes can complicate treatment options for infections, particularly in polymicrobial environments. Medical Applications: While Thomasclavelia spiroformis itself has not been directly linked to probiotics or therapeutics, its relatives are often studied for their beneficial roles in gut health. Understanding the functions of Thomasclavelia spiroformis could contribute to the development of novel probiotic therapies aimed at restoring gut microbiota balance. In summary, while Thomasclavelia spiroformis is not yet well-characterized in clinical contexts, its potential roles in human health, pathogenicity, and antimicrobial resistance warrant further investigation to fully understand its implications in microbiome-related health and disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Thomasclavelia spiroformis is a fascinating microorganism primarily associated with marine environments, particularly in the context of benthic ecosystems. This organism thrives in the sediment layers of coastal regions, where it plays a crucial role in nutrient cycling and organic matter decomposition. Its presence is often linked to areas with rich organic substrates, such as those found in estuaries and mangrove swamps, where it contributes to the breakdown of complex organic materials, thus facilitating nutrient availability for other organisms in the ecosystem. In these benthic habitats, T. spiroformis exhibits notable interactions with its surroundings. It is known to engage in symbiotic relationships with various marine invertebrates, aiding in their nutrient acquisition while benefiting from the organic waste produced by these hosts. This mutualistic interaction highlights the organism's role in enhancing the overall productivity of the ecosystem. Furthermore, T. spiroformis demonstrates remarkable environmental adaptation capabilities, allowing it to thrive in varying conditions of salinity and temperature typical of coastal marine environments. Its resilience contributes to the stability of the microbial community, making it an essential player in maintaining the health of its biome. Overall, the ecological significance of Thomasclavelia spiroformis in marine benthic ecosystems cannot be overstated, as it underpins various biological processes that sustain marine life.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Thomasclavelia spiroformis has shown potential in various industrial applications across multiple sectors. One of the most notable areas is biotechnology, where Thomasclavelia spiroformis is utilized in fermentation processes to produce valuable metabolites. This organism can be harnessed to synthesize organic acids, which are essential in the production of biodegradable plastics and other biopolymers. In the realm of waste management, Thomasclavelia spiroformis has demonstrated capabilities in biodegradation of complex organic compounds, making it a candidate for bioremediation efforts. Its ability to break down pollutants in contaminated environments can aid in the detoxification of industrial waste, thus contributing to environmental sustainability. Furthermore, the organism has potential in biofuel production. Through fermentation, Thomasclavelia spiroformis can convert biomass into bioethanol, providing a renewable energy source that can help reduce reliance on fossil fuels. This process not only contributes to energy sustainability but also promotes the use of waste materials as feedstock. In pharmaceutical development, the enzymatic activity of Thomasclavelia spiroformis can be explored for the production of bioactive compounds. These compounds may have therapeutic properties, making the organism a valuable resource in drug discovery and development. Overall, Thomasclavelia spiroformis presents a multifaceted potential in various industries, particularly in biotechnology, waste management, biofuel production, and pharmaceutical development, through its involvement in fermentation, biodegradation, and enzymatic processes.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	openai/gpt-3.5-turbo-0125	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	google/gemini-pro	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	google/gemma-7b-it	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	N/A	true	true	true	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Gram staining	gram stain positive	gram stain negative ✗	gram stain negative ✗	gram stain negative ✗	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	gram stain variable ✗	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗
Aerophilicity	anaerobic	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	anaerobic ✓	anaerobic ✓	aerobic ✗	aerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	false	true	true	false	false	false	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Biosafety level	N/A	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2
Health association	FALSE	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Host association	TRUE	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	beta	beta	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	spirillum	spirillum	spirillum	spirillum	spirillum	spirillum	spirillum	spirillum	bacillus	bacillus	spirillum	spirillum	spirillum	spirillum	spirillum	spirillum	bacillus	bacillus	spirillum	spirillum	spirillum	spirillum	spirillum	spirillum	spirillum	spirillum	spirillum	spirillum

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