Bifidobacterium choerinum

General Information

Bifidobacterium choerinum is a fascinating microorganism primarily known for its presence in the gastrointestinal tracts of pigs. This bacterium belongs to the genus Bifidobacterium, which is renowned for its probiotic properties and significant role in maintaining gut health. One of the most interesting aspects of B. choerinum is its potential application in veterinary probiotics, aimed at improving the digestive health and overall well-being of livestock. B. choerinum is characterized by its ability to produce lactic acid and acetic acid through the fermentation of carbohydrates, which helps in lowering the pH of the gut environment. This acidic environment can inhibit the growth of pathogenic bacteria, thereby promoting a healthier gut microbiota. The production of these organic acids is a key feature that underscores the probiotic potential of B. choerinum. Another unique characteristic of B. choerinum is its genetic makeup, which includes genes responsible for the synthesis of exopolysaccharides (EPS). These EPS molecules can play a crucial role in the adhesion of the bacteria to the gut lining, enhancing their colonization and persistence in the gastrointestinal tract. This adhesion capability is particularly valuable for the development of effective probiotic formulations. From a research perspective, B. choerinum offers valuable insights into the symbiotic relationships between host animals and their gut microbiota. Studies on this bacterium can contribute to a better understanding of how probiotics can be tailored to specific hosts, leading to more effective and targeted probiotic therapies. The exploration of B. choerinum's metabolic pathways and genetic traits continues to be a promising area of research, with potential applications in both animal and human health. In summary, Bifidobacterium choerinum stands out due to its probiotic potential, ability to produce beneficial organic acids, and unique genetic traits that facilitate gut colonization. These characteristics make it a valuable subject of study in the field of microbiology and probiotics.

Bifidobacterium choerinum is a fascinating species of bacteria that belongs to the genus Bifidobacterium, which is well-known for its role in the gut microbiota of various animals, including humans. This particular species is primarily isolated from the intestines of pigs, making it particularly interesting for studies related to animal health and nutrition. Its presence in the gut of swine suggests a potential role in digestion and nutrient absorption, which could have implications for livestock management and feed efficiency. One of the unique aspects of B. choerinum is its ability to ferment a variety of carbohydrates, producing short-chain fatty acids (SCFAs) such as acetate and propionate. These SCFAs are crucial for maintaining gut health, as they serve as energy sources for colonocytes and play a role in regulating immune responses. This metabolic capability makes B. choerinum a valuable candidate for research into probiotics and their potential benefits in both animal and human health. Furthermore, studies on B. choerinum can provide insights into the evolution of gut microbiota in mammals, particularly in relation to dietary habits and the domestication of animals. Understanding the specific functions and interactions of this bacterium within the gut ecosystem can lead to advancements in microbiome research and the development of targeted therapies for gastrointestinal disorders. Overall, Bifidobacterium choerinum stands out as a significant organism for both agricultural and biomedical research, highlighting the intricate relationships between diet, gut microbiota, and health.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Bifidobacteriales

Family: Bifidobacteriaceae

Genus: Bifidobacterium

Species: Bifidobacterium choerinum

NCBI ID

35760

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/761/235/GCF_002761235.1_ASM276123v1

File for sequence-based predictions:
GCF_002761235.1_ASM276123v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Bifidobacterium choerinum is a member of the Bifidobacterium genus, which is known for its role in human gut health. This organism is primarily associated with the gastrointestinal tract and is considered a beneficial bacterium. Its clinical implications are significant in the context of gut microbiota and overall human health. Role in Human Health: Bifidobacterium choerinum contributes to the maintenance of a balanced gut microbiome, which is essential for proper digestion and nutrient absorption. It is known to produce short-chain fatty acids (SCFAs) that are beneficial for colonic health and may help in regulating inflammation in the gut. Disease Associations: While specific disease associations with Bifidobacterium choerinum are not extensively documented, members of the Bifidobacterium genus are generally linked to a reduced risk of gastrointestinal disorders such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Pathogenicity: Bifidobacterium choerinum is not considered pathogenic; rather, it is classified as a probiotic. Probiotics are live microorganisms that confer health benefits to the host, particularly in the prevention and treatment of various gastrointestinal conditions. Antimicrobial Resistance: There is limited information regarding antimicrobial resistance in Bifidobacterium choerinum. However, the Bifidobacterium genus is generally regarded as having low levels of resistance to antibiotics, which is advantageous for its use in probiotic formulations. Medical Applications: The potential applications of Bifidobacterium choerinum in probiotics are noteworthy. It may be used in dietary supplements aimed at enhancing gut health and restoring microbial balance, especially after antibiotic treatment. Additionally, ongoing research is exploring its role in therapeutics for various gastrointestinal conditions. Immune Evasion Strategies: While specific immune evasion strategies of Bifidobacterium choerinum are not well-documented, Bifidobacteria, in general, are known to modulate the immune response by promoting the production of anti-inflammatory cytokines and enhancing the activity of regulatory T cells. This modulation can help in maintaining gut homeostasis and preventing excessive inflammatory responses. In summary, Bifidobacterium choerinum plays a crucial role in promoting gut health and may have therapeutic potential in managing gastrointestinal disorders, although further research is needed to fully elucidate its clinical relevance.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Bifidobacterium choerinum is a species of bacteria commonly found in the gastrointestinal tract of various mammals, particularly in the intestines of pigs. This microorganism plays a crucial role in the maintenance of gut health and is associated with several important ecological niches. Intestinal Microbiome: - Within the intestinal microbiome, _Bifidobacterium choerinum contributes to the fermentation of dietary fibers, producing short-chain fatty acids (SCFAs) that are beneficial for the host's health. These SCFAs serve as an energy source for colonocytes and help maintain the integrity of the gut barrier. - The presence of Bifidobacterium choerinum is often linked to a balanced gut microbiota, which is essential for preventing dysbiosis and associated gastrointestinal disorders. Symbiotic Relationships: - This bacterium exhibits symbiotic relationships with other gut microbiota, enhancing the overall microbial diversity and stability of the gut ecosystem. It can inhibit the growth of pathogenic bacteria through competitive exclusion and the production of antimicrobial substances. Adaptation to Host Environment: - Bifidobacterium choerinum has adapted to thrive in the anaerobic conditions of the intestines, where it can efficiently metabolize complex carbohydrates. Its ability to survive in such environments is crucial for its role in digestion and nutrient absorption. Overall, Bifidobacterium choerinum is a vital component of the gut microbiome, contributing to the health and well-being of its host through various ecological interactions and adaptations.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Bifidobacterium choerinum has shown significant potential in various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This species is known for its role in the human gut microbiome, contributing to gut health and influencing metabolic processes. Its ability to produce beneficial metabolites makes it a candidate for use in fermentation processes aimed at developing functional foods and probiotics. In the realm of biotechnology, Bifidobacterium choerinum can be utilized in the production of probiotic supplements that enhance gut flora, thereby improving digestion and overall health. The organism's capacity to ferment dietary fibers into short-chain fatty acids (SCFAs) is particularly valuable, as SCFAs are known to have anti-inflammatory properties and can support immune function. Moreover, in pharmaceutical development, the metabolites produced by Bifidobacterium choerinum may have therapeutic effects, leading to the exploration of this microorganism in the formulation of new drugs aimed at treating gastrointestinal disorders. In terms of waste management, while not its primary application, the metabolic pathways of Bifidobacterium choerinum could potentially be harnessed for the biodegradation of certain organic waste materials, contributing to more sustainable waste treatment solutions. Overall, the diverse capabilities of Bifidobacterium choerinum in these areas highlight its importance in advancing health and environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	meta-llama/llama-3-70b-instruct:nitro	google/palm-2-chat-bison-32k	anthropic/claude-3-haiku:beta	google/gemini-flash-1.5	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/gemma-7b-it	google/gemma-7b-it
Motility	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	anaerobic	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	aerotolerant ✗	aerotolerant ✗	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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