Corynebacterium pseudogenitalium

General Information

Corynebacterium pseudogenitalium is a bacterium that belongs to the genus Corynebacterium, which is known for its diverse range of species that inhabit various environments, including soil, water, and the human body. One of the most interesting aspects of C. pseudogenitalium is its potential role in the human microbiome, particularly in the urogenital tract. While it is not typically associated with disease, its presence and interactions with other microbial communities can provide valuable insights into microbial ecology and the balance of commensal organisms in the human body. From a research perspective, C. pseudogenitalium is valuable for studying microbial diversity and host-microbe interactions. Its relatively low pathogenicity makes it a suitable candidate for exploring how non-pathogenic bacteria coexist with their hosts and contribute to overall health. Additionally, understanding the genetic and metabolic pathways of C. pseudogenitalium can shed light on the evolutionary adaptations that allow it to thrive in specific niches. Another unique characteristic of C. pseudogenitalium is its potential use in biotechnological applications. Members of the Corynebacterium genus are known for their ability to produce various biochemicals, and studying C. pseudogenitalium could lead to the discovery of novel enzymes or metabolic products that have industrial or pharmaceutical relevance. This makes it an exciting subject for researchers looking to harness microbial capabilities for practical applications. In summary, Corynebacterium pseudogenitalium is a fascinating organism due to its role in the human microbiome, its contributions to our understanding of microbial ecology, and its potential in biotechnological innovations. Its study not only enhances our knowledge of microbial diversity but also opens up new avenues for practical applications in science and industry.

Corynebacterium pseudogenitalium is a fascinating member of the Corynebacterium genus, notable for its unique ecological niche and potential implications in human health. This organism is primarily found in the human urogenital tract, where it plays a role in the complex microbial community. Its presence in this environment raises interesting questions about its interactions with other microorganisms and its potential impact on urogenital health. One of the most intriguing aspects of C. pseudogenitalium is its ability to adapt to the specific conditions of the urogenital microbiome. This adaptability may provide insights into microbial resilience and the mechanisms by which certain bacteria thrive in specialized environments. Furthermore, research into this species could shed light on its role in maintaining the balance of the microbiome, which is crucial for preventing infections and promoting overall health. Additionally, C. pseudogenitalium has been studied for its metabolic capabilities, particularly in the context of its potential to produce bioactive compounds. These compounds may have applications in biotechnology and medicine, making this organism a valuable subject for further research. Understanding the metabolic pathways and genetic makeup of C. pseudogenitalium could lead to discoveries that enhance our knowledge of microbial interactions and their implications for human health. In summary, Corynebacterium pseudogenitalium stands out due to its specific habitat, adaptability, and potential contributions to our understanding of the human microbiome and its associated health outcomes. Its study could pave the way for novel therapeutic strategies and a deeper comprehension of microbial ecology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Corynebacteriaceae

Genus: Corynebacterium

Species: Corynebacterium pseudogenitalium

NCBI ID

38303

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/024/453/815/GCF_024453815.1_ASM2445381v1

File for sequence-based predictions:
GCF_024453815.1_ASM2445381v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Corynebacterium pseudogenitalium is a member of the genus Corynebacterium, which includes various species known for their role in human health and disease. While Corynebacterium pseudogenitalium is less studied compared to its relatives, it has been associated with certain clinical implications. It is primarily recognized as a commensal organism found in the human urogenital tract, where it may play a role in maintaining the microbiome balance. However, its presence has also been linked to infections in immunocompromised individuals, particularly in cases of bacterial vaginosis or other urogenital infections. Pathogenicity of Corynebacterium pseudogenitalium is not well-documented, but like other Corynebacteria, it may possess virulence factors that enable it to evade the host's immune response. This includes the ability to form biofilms, which can protect the bacteria from antimicrobial agents and the host's immune system. In terms of antimicrobial resistance, there is limited data available, but the genus Corynebacterium is known to exhibit varying degrees of resistance to common antibiotics, which raises concerns for treatment options in infected patients. Currently, there are no established medical applications such as probiotics or vaccines specifically targeting Corynebacterium pseudogenitalium. However, understanding its role in the urogenital microbiome may provide insights into potential therapeutic strategies for managing infections associated with dysbiosis. Further research is needed to clarify its clinical significance and potential implications in human health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Corynebacterium pseudogenitalium is primarily associated with the human urogenital tract, where it is part of the normal microbiota. This microorganism thrives in the moist, nutrient-rich environments of the mucosal surfaces, particularly in the vaginal and urethral regions. Its presence is often linked to maintaining a balanced microbial community, which is crucial for preventing the overgrowth of pathogenic organisms. In this biome, Corynebacterium pseudogenitalium plays a significant role in symbiosis, contributing to the overall health of the host by competing with harmful bacteria and producing metabolites that can inhibit their growth. The organism's ability to adapt to varying pH levels and nutrient availability in the urogenital environment showcases its ecological flexibility. Additionally, this bacterium may interact with other members of the microbiota, forming complex relationships that can influence the host's immune response and overall health. Its presence is particularly noted in individuals with a healthy microbiome, highlighting its importance in maintaining microbial diversity and ecosystem stability within the urogenital tract.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Corynebacterium pseudogenitalium has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to participate in fermentation processes, which can be harnessed for the production of valuable metabolites such as amino acids and vitamins. For instance, its metabolic pathways can be utilized to enhance the yield of specific compounds during fermentation, making it a candidate for use in the food and feed industries. In the realm of waste management, Corynebacterium pseudogenitalium has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic materials. This property can be leveraged in the treatment of wastewater, where the microorganism can help in the degradation of pollutants, thus contributing to more sustainable waste management practices. Moreover, the enzymatic activity of Corynebacterium pseudogenitalium can be explored for pharmaceutical development. The organism may produce enzymes that can be utilized in the synthesis of pharmaceutical compounds or in the bioconversion of raw materials into more complex drugs. This aspect highlights its potential role in the biotechnology sector, where enzyme production is crucial for various industrial processes. Overall, Corynebacterium pseudogenitalium presents a multifaceted opportunity for application in biofuel production, biodegradation, and enzyme production, making it a valuable organism for future industrial innovations.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	anthropic/claude-3-haiku:beta	mistralai/mixtral-8x7b-instruct:nitro	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	openchat/openchat-7b	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-flash-1.5	google/gemini-flash-1.5	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	openai/gpt-4o	openai/gpt-4o	openai/gpt-4	openai/gpt-4	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	google/gemini-pro	google/gemini-pro
Motility	N/A	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	aerotolerant ✗	aerotolerant ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Animal pathogenicity	FALSE	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biosafety level	N/A	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2
Health association	N/A	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

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