Corynebacterium glucuronolyticum

General Information

Corynebacterium glucuronolyticum is a fascinating microorganism that has garnered attention due to its unique biochemical properties and clinical significance. This bacterium is part of the genus Corynebacterium, which includes many species known for their diverse metabolic capabilities and roles in human health and disease. One of the key characteristics of C. glucuronolyticum is its ability to hydrolyze glucuronic acid, a trait that is relatively rare among bacteria. This enzymatic activity is not only interesting from a biochemical perspective but also has potential implications for biotechnological applications, particularly in the degradation of complex carbohydrates and the production of bioactive compounds. Clinically, C. glucuronolyticum has been isolated from various human infections, including urogenital tract infections. Its presence in these infections highlights its potential role as an opportunistic pathogen. Understanding the pathogenic mechanisms of C. glucuronolyticum can provide insights into the management and treatment of infections caused by this bacterium. Moreover, the study of C. glucuronolyticum contributes to the broader understanding of the Corynebacterium genus, which includes both harmless commensals and significant pathogens like Corynebacterium diphtheriae. By exploring the genetic and metabolic diversity within this genus, researchers can uncover new strategies for combating bacterial infections and harnessing beneficial microbial processes. In summary, Corynebacterium glucuronolyticum is a noteworthy bacterium due to its unique enzymatic activity, clinical relevance, and the broader implications of its study for microbiology and biotechnology.

Corynebacterium glucuronolyticum is a fascinating member of the Corynebacterium genus, notable for its unique metabolic capabilities. This organism is particularly interesting due to its ability to degrade glucuronate, a sugar acid that is a component of various polysaccharides and glycosaminoglycans. This metabolic pathway not only highlights the organism's ecological role in the degradation of complex carbohydrates but also suggests potential applications in bioremediation and waste treatment processes. One of the most valuable aspects of C. glucuronolyticum is its potential in the field of biotechnology. The enzymes involved in glucuronate metabolism could be harnessed for industrial applications, such as the production of biofuels or the bioconversion of plant materials into useful products. Furthermore, the study of this organism can provide insights into the evolution of metabolic pathways in bacteria, particularly those involved in carbohydrate metabolism. Additionally, C. glucuronolyticum has been isolated from human sources, which raises interesting questions about its role in the human microbiome. Understanding its interactions within the gut environment could lead to discoveries about its contributions to human health or disease. This aspect makes it a valuable subject for research in microbiology and human health, particularly in the context of gut microbiota and its implications for metabolic disorders. In summary, Corynebacterium glucuronolyticum stands out due to its unique metabolic capabilities, potential biotechnological applications, and its relevance to human health, making it a significant organism for further study in various scientific fields.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Corynebacteriaceae

Genus: Corynebacterium

Species: Corynebacterium glucuronolyticum

NCBI ID

39791

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/016/728/645/GCA_016728645.1_ASM1672864v1

File for sequence-based predictions:
GCA_016728645.1_ASM1672864v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Corynebacterium glucuronolyticum is a member of the genus Corynebacterium, which includes various species known for their role in human health and disease. While C. glucuronolyticum is less studied compared to other members of the genus, it has been associated with certain clinical implications. Clinical relevance primarily arises from its potential role in infections and its presence in human microbiota. It has been isolated from clinical specimens, suggesting a possible association with opportunistic infections, particularly in immunocompromised patients. One of the notable aspects of C. glucuronolyticum is its ability to metabolize glucuronate, which may play a role in its survival and colonization in the human body. This metabolic capability could influence the organism's interaction with the host's immune response, potentially aiding in immune evasion strategies. In terms of antimicrobial resistance, there is limited data available, but like many Corynebacterium species, it may exhibit resistance to certain antibiotics, which poses challenges in treatment. The presence of such organisms in clinical settings underscores the importance of ongoing surveillance and research to better understand their pathogenic potential and resistance mechanisms. Currently, there are no well-documented medical applications such as probiotics or vaccines specifically associated with C. glucuronolyticum. However, its role in the human microbiome and potential implications in disease associations warrant further investigation to clarify its clinical significance.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Corynebacterium glucuronolyticum is a bacterium commonly found in various human-associated environments and is particularly notable for its role in the gut microbiome. This microorganism thrives in the anaerobic conditions of the intestines, where it contributes to the breakdown of complex carbohydrates and the fermentation of dietary fibers. Its presence is often linked to the degradation of glucuronides, which are compounds that can be found in various foods and medications, thus playing a significant role in metabolic processes within the gut ecosystem. In terms of ecological interactions, Corynebacterium glucuronolyticum may engage in symbiotic relationships with other gut microbiota, aiding in nutrient absorption and promoting a balanced microbial community. This bacterium can also influence the host's immune response and overall gut health, highlighting its importance in maintaining homeostasis within the gastrointestinal tract. Additionally, this organism has been studied for its potential in bioremediation processes, where it may help in the breakdown of environmental pollutants, showcasing its adaptability to various ecological niches beyond the human body. Overall, Corynebacterium glucuronolyticum exemplifies the intricate relationships microorganisms have with their environments and their essential roles in both health and ecological balance.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Corynebacterium glucuronolyticum has shown significant potential in various industrial applications. One of the primary areas of interest is in biotechnology, where it is utilized for its ability to degrade complex carbohydrates, particularly in the context of biodegradation. This capability makes it valuable in waste management processes, where it can help break down organic materials in landfills or wastewater treatment facilities, thus contributing to more sustainable waste management practices. In addition, Corynebacterium glucuronolyticum is known for its role in fermentation processes, particularly in the production of biofuels. By converting biomass into fermentable sugars, this microorganism can facilitate the production of ethanol and other biofuels, which are essential for reducing reliance on fossil fuels and promoting renewable energy sources. Furthermore, the enzymatic activity of Corynebacterium glucuronolyticum is of interest in pharmaceutical development. The organism can produce specific enzymes that may be harnessed for the synthesis of pharmaceutical compounds, enhancing the efficiency and sustainability of drug production. Overall, the diverse capabilities of Corynebacterium glucuronolyticum in biodegradation, fermentation, and enzyme production highlight its potential as a valuable asset in various industries, including biotechnology, waste management, and pharmaceuticals.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/gemma-7b-it	openchat/openchat-7b	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-pro	google/gemini-pro
Motility	N/A	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	N/A	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	false	true	false	false	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	beta	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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