Prevotella amnii

General Information

Prevotella amnii is a fascinating microorganism that belongs to the genus Prevotella, which is known for its diverse roles in human health and disease. This species is particularly interesting due to its association with the human reproductive tract. One of the most notable aspects of P. amnii is its involvement in bacterial vaginosis (BV), a common condition characterized by an imbalance in the vaginal microbiota. P. amnii has been identified in the amniotic fluid of pregnant women, suggesting a potential role in adverse pregnancy outcomes such as preterm birth. This makes it a subject of significant interest in obstetric research. The ability of P. amnii to thrive in the unique environment of the human reproductive system highlights its adaptability and the complex interactions it has with the host's immune system and other microbial communities. From a metabolic perspective, P. amnii is known for its ability to break down complex carbohydrates and proteins, contributing to the nutrient dynamics within its niche. This metabolic versatility is a hallmark of the Prevotella genus and underscores the ecological importance of these bacteria in maintaining microbial balance. Research into P. amnii is valuable not only for understanding its role in disease but also for exploring potential therapeutic interventions. By studying the mechanisms through which P. amnii interacts with the host and other microbes, scientists hope to develop targeted treatments that can restore healthy microbial communities and prevent conditions like BV and preterm birth. In summary, Prevotella amnii is a microorganism of significant interest due to its association with the human reproductive tract, its potential impact on pregnancy outcomes, and its metabolic capabilities. Its study offers valuable insights into microbial ecology, host-microbe interactions, and potential therapeutic strategies.

Prevotella amnii is a fascinating member of the genus Prevotella, which is known for its role in the human microbiome, particularly in the gastrointestinal tract. This anaerobic bacterium is notable for its ability to metabolize a variety of carbohydrates and proteins, contributing to the complex ecosystem of gut microbiota. One of the most interesting aspects of Prevotella amnii is its association with various health conditions, including its potential involvement in inflammatory diseases and its role in the metabolism of dietary components. The species is also recognized for its unique enzymatic capabilities, particularly in the breakdown of complex polysaccharides, which can influence nutrient absorption and overall gut health. Research has shown that Prevotella amnii may play a role in the modulation of immune responses, making it a valuable subject for studies related to immunology and gut health. Furthermore, Prevotella amnii has been isolated from various environments, including the human oral cavity and the gastrointestinal tract of ruminants, highlighting its ecological versatility. This adaptability makes it an interesting candidate for studies on microbial ecology and evolution. Understanding the interactions of Prevotella amnii within the microbiome could provide insights into its potential therapeutic applications, particularly in the context of dysbiosis and related diseases. Overall, Prevotella amnii stands out as a significant organism for research in microbiology, nutrition, and health sciences.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacteroidota

Class: Bacteroidia

Order: Bacteroidales

Family: Prevotellaceae

Genus: Prevotella

Species: Prevotella amnii

NCBI ID

419005

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/553/225/GCF_001553225.1_ASM155322v1

File for sequence-based predictions:
GCF_001553225.1_ASM155322v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Prevotella amnii is part of the normal flora of the human gastrointestinal tract and has been associated with various clinical implications. It is known to play a role in human health by contributing to the maintenance of gut homeostasis and influencing the immune system. However, it has also been implicated in several disease associations, particularly in cases of bacterial vaginosis and other infections of the reproductive tract. Its presence has been linked to inflammatory conditions and may contribute to the pathogenesis of chronic diseases such as periodontal disease and inflammatory bowel disease. In terms of pathogenicity, Prevotella amnii can exhibit virulence factors that enable it to evade the host's immune response, including the production of proteolytic enzymes and the ability to form biofilms. These characteristics can complicate treatment and contribute to persistent infections. Furthermore, there is growing concern regarding antimicrobial resistance among members of the Prevotella genus, which may limit the effectiveness of standard antibiotic therapies. While Prevotella amnii is not commonly used in medical applications like probiotics or vaccines, understanding its role in the microbiome is crucial for developing targeted therapies and improving patient outcomes in conditions associated with dysbiosis. Continued research into its interactions with the human body and its potential contributions to disease mechanisms is essential for advancing clinical knowledge and treatment strategies.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Prevotella amnii is a species of bacteria commonly found in the gastrointestinal tract of mammals, particularly in the intestines of ruminants such as cattle and sheep. This microorganism thrives in a microaerophilic environment, where oxygen levels are low, which is typical of the anaerobic conditions present in the gut. Its presence is crucial for the breakdown of complex carbohydrates, contributing to the overall digestive health of its host. In terms of ecological niches, Prevotella amnii plays a significant role in the rumen microbiome, where it aids in the fermentation process, helping to convert fibrous plant material into volatile fatty acids that serve as an energy source for the host. This symbiotic relationship is vital for the nutrition of ruminants, showcasing the importance of Prevotella amnii in nutrient cycling within this biome. Additionally, Prevotella amnii can be involved in interactions with other gut microbiota, contributing to the overall microbial diversity and stability of the gut ecosystem. Its ability to adapt to varying dietary conditions allows it to thrive in different environments, making it a key player in the health and function of the gastrointestinal ecosystem.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Prevotella amnii has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is part of the gut microbiota and plays a significant role in the fermentation of carbohydrates, which can be harnessed for the production of bioactive compounds. In biotechnology, Prevotella amnii can be utilized in the development of probiotics, contributing to gut health and enhancing the immune response. Its ability to ferment dietary fibers can lead to the production of short-chain fatty acids (SCFAs), which are beneficial for human health and can be explored for functional food development. In the realm of waste management, Prevotella amnii has been studied for its role in biodegradation processes, particularly in the breakdown of complex organic materials in anaerobic environments. This capability can be applied in the treatment of organic waste, helping to reduce landfill contributions and enhance composting processes. Furthermore, the enzymatic activities of Prevotella amnii can be leveraged in biofuel production, where its fermentation processes can convert biomass into bioethanol or biogas, providing a sustainable energy source. The organism's efficiency in fermentation makes it a candidate for optimizing biofuel production pathways. Overall, Prevotella amnii presents a promising avenue for innovation in pharmaceutical development, particularly in the formulation of new therapeutic agents derived from its metabolic byproducts, as well as in enhancing the efficacy of existing drugs through its interactions within the gut microbiome.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	mistralai/mistral-7b-instruct	google/gemma-7b-it	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openai/gpt-4	openai/gpt-4	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	N/A	false	true	false	false	true	true	true	true	true	false	false	false	false	false	false	false	false	true	true	false	false	true	true	true	true	false	false
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	anaerobic	anaerobic ✓	aerotolerant ✗	N/A	anaerobic ✓	aerotolerant ✗	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Animal pathogenicity	TRUE	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	N/A	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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