Corynebacterium striatum

General Information

Corynebacterium striatum is a fascinating microorganism that has garnered significant attention in recent years due to its emerging role as an opportunistic pathogen. One of the most intriguing aspects of C. striatum is its ability to cause a wide range of infections in humans, particularly in immunocompromised individuals. These infections can range from respiratory tract infections to more severe conditions such as endocarditis and septicemia. Another notable characteristic of C. striatum is its remarkable adaptability and resistance to multiple antibiotics. This resistance makes it a challenging pathogen to treat and highlights the importance of ongoing research to develop effective therapeutic strategies. The organism's genome has been sequenced, providing valuable insights into its resistance mechanisms and potential targets for new antibiotics. From a research perspective, C. striatum is also interesting due to its ability to form complex communities with other microorganisms. This interaction can influence the pathogenicity and resistance profiles of the microbial community, making it a valuable model for studying microbial ecology and interspecies interactions. In addition to its clinical significance, C. striatum has been studied for its potential applications in biotechnology. For instance, some strains have been explored for their ability to produce valuable biochemicals, such as amino acids and enzymes, which can be utilized in various industrial processes. Overall, Corynebacterium striatum is a microorganism of considerable interest due to its clinical relevance, antibiotic resistance, and potential biotechnological applications. Continued research on this organism is essential to fully understand its biology and to develop effective strategies for managing infections and harnessing its biotechnological potential.

Corynebacterium striatum is a noteworthy member of the genus Corynebacterium, primarily recognized for its role as a commensal organism in human skin and mucosal surfaces. This bacterium is particularly interesting due to its emerging significance as an opportunistic pathogen, especially in immunocompromised individuals. Its ability to cause infections, particularly in patients with underlying health conditions, highlights the need for further research into its pathogenic mechanisms and virulence factors. One of the unique aspects of C. striatum is its resistance to multiple antibiotics, which poses challenges in clinical settings. This resistance is often attributed to the presence of specific genetic determinants that can be transferred between bacterial species, making it a subject of interest in studies focused on antibiotic resistance and the evolution of pathogenic traits. Additionally, C. striatum has been implicated in various infections, including skin and soft tissue infections, respiratory tract infections, and even endocarditis. Its ability to form biofilms on medical devices and tissues further complicates treatment options, making it a valuable organism for research into biofilm-related infections. The organism's genomic characteristics have also been a focus of study, revealing insights into its metabolic pathways and potential for adaptation to different environments. Understanding these genomic features can provide valuable information for developing targeted therapies and improving infection control measures. In summary, Corynebacterium striatum stands out not only for its role as a commensal organism but also for its potential to cause opportunistic infections, its antibiotic resistance, and its genomic adaptability, making it a significant subject of research in microbiology and infectious disease.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Corynebacteriaceae

Genus: Corynebacterium

Species: Corynebacterium striatum

NCBI ID

43770

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/016/728/105/GCA_016728105.1_ASM1672810v1

File for sequence-based predictions:
GCA_016728105.1_ASM1672810v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Corynebacterium striatum is a member of the normal flora of the human skin and mucous membranes, but it has gained attention due to its potential role in infections and its association with various clinical conditions. C. striatum is known to be an opportunistic pathogen, particularly in immunocompromised patients, and has been implicated in nosocomial infections, including pneumonia, bacteremia, and skin infections. Its pathogenicity is often linked to its ability to form biofilms and its capacity to survive in harsh environments, which can complicate treatment options. One of the significant concerns regarding Corynebacterium striatum is its antimicrobial resistance. This organism has shown resistance to multiple antibiotics, including beta-lactams and macrolides, which poses a challenge in clinical settings. The mechanisms of resistance are often attributed to the acquisition of resistance genes and the presence of efflux pumps, which can expel antibiotics from the bacterial cell, thereby reducing their efficacy. In terms of immune evasion, Corynebacterium striatum can modulate the host immune response, allowing it to persist in the host despite the presence of immune cells. This ability to evade the immune system contributes to its role as an opportunistic pathogen, particularly in patients with underlying health conditions. Despite its pathogenic potential, there is ongoing research into the beneficial aspects of Corynebacterium striatum as a part of the human microbiome. Some studies suggest that certain strains may have probiotic properties, which could be harnessed for therapeutic applications. However, more research is needed to fully understand the balance between its pathogenic and beneficial roles in human health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Corynebacterium striatum is a bacterium commonly associated with the human microbiome, particularly in the skin and respiratory tract. This organism thrives in environments that are rich in nutrients and moisture, making it well-suited for colonization on the skin surface and mucosal membranes. It is often found in areas of the body that are warm and moist, such as the armpits, groin, and between toes, where it can form part of the normal flora. In the context of its ecological role, Corynebacterium striatum is known to participate in the maintenance of skin health by competing with pathogenic microorganisms, thus playing a protective role in the skin biome. Its presence can help to prevent infections by outcompeting harmful bacteria for resources and space. Additionally, this bacterium has been documented in the oral cavity, where it may contribute to the complex microbial community that resides there. Its interactions with other microorganisms can lead to symbiotic relationships, where it may benefit from the metabolic byproducts of other bacteria while also contributing to the overall balance of the microbial ecosystem. Furthermore, Corynebacterium striatum has shown adaptability to various environmental conditions, which allows it to thrive in diverse habitats within the human body. Its ability to form biofilms can enhance its survival in fluctuating environments, making it a resilient member of the microbial community. Overall, Corynebacterium striatum exemplifies the intricate relationships that microorganisms have with their hosts and the environments they inhabit.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Corynebacterium striatum has shown potential in various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This organism is known for its ability to produce a range of bioactive compounds, which can be harnessed in the production of antibiotics and other therapeutic agents. For instance, its metabolic pathways can be exploited for the fermentation of specific substrates to yield valuable metabolites. In the realm of waste management, Corynebacterium striatum has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic materials. This property can be utilized in the treatment of wastewater, where the microorganism can help in the degradation of pollutants, thus contributing to more sustainable waste management practices. Moreover, its enzymatic activity is noteworthy, as it can produce enzymes that are useful in various industrial processes, including the food industry for enzyme production that enhances food processing and preservation. Overall, Corynebacterium striatum presents a promising avenue for innovation in these sectors, leveraging its natural capabilities for industrial benefit.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	meta-llama/llama-3-70b-instruct:nitro	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	mistralai/mistral-7b-instruct	google/gemini-pro	openai/gpt-4o	openai/gpt-4o	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	openchat/openchat-7b	openchat/openchat-7b	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false	true	true	false	false	false	false
Gram staining	gram stain positive	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true
Animal pathogenicity	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	beta	beta	beta	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus	coccus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus

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