Fluoribacter dumoffii

General Information

Fluoribacter dumoffii is a fascinating microorganism primarily known for its role as a human pathogen. This bacterium is a member of the Legionellaceae family and is closely related to Legionella pneumophila, the causative agent of Legionnaires' disease. One of the most intriguing aspects of F. dumoffii is its ability to cause a similar type of pneumonia, often referred to as Legionellosis, which can be severe and sometimes fatal. What makes Fluoribacter dumoffii particularly interesting is its environmental versatility. It is commonly found in aquatic environments, including natural water bodies and man-made water systems such as cooling towers, hot tubs, and plumbing systems. This adaptability to various water sources makes it a significant concern for public health, especially in settings where water systems are not properly maintained. Another unique characteristic of F. dumoffii is its intracellular lifestyle. It can infect and replicate within amoebae, which serve as a natural reservoir and a means of protection against harsh environmental conditions. This intracellular replication is also a key factor in its pathogenicity in humans, as it can invade and multiply within macrophages, evading the host's immune response. From a research perspective, Fluoribacter dumoffii is valuable for studying host-pathogen interactions, particularly the mechanisms of intracellular survival and replication. Understanding these processes can provide insights into the development of new therapeutic strategies and preventive measures against Legionellosis. In summary, Fluoribacter dumoffii is a noteworthy microorganism due to its pathogenic potential, environmental resilience, and intracellular lifestyle, making it a significant subject of study in microbiology and infectious disease research.

Fluoribacter dumoffii is a fascinating bacterium that belongs to the family of Fluoribacteraceae. This organism is particularly notable for its ability to thrive in environments rich in organic matter, often found in aquatic ecosystems. One of the most interesting aspects of F. dumoffii is its unique metabolic capabilities, which allow it to utilize a variety of carbon sources, making it a valuable subject for studies on microbial ecology and biogeochemical cycles. The bacterium is also recognized for its potential applications in bioremediation, as it can degrade complex organic pollutants. This characteristic positions F. dumoffii as a promising candidate for environmental cleanup efforts, particularly in contaminated water bodies. Moreover, F. dumoffii has been studied for its role in the microbial community dynamics, contributing to our understanding of how microorganisms interact within their ecosystems. Its adaptability to different environmental conditions makes it a model organism for research in microbial physiology and ecology. The insights gained from studying F. dumoffii could lead to advancements in biotechnology and environmental management, highlighting its significance in both scientific research and practical applications.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Gammaproteobacteria

Order: Legionellales

Family: Legionellaceae

Genus: Fluoribacter

Species: Fluoribacter dumoffii

NCBI ID

463

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/900/450/695/GCA_900450695.1_48903_A01

File for sequence-based predictions:
GCA_900450695.1_48903_A01_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Fluoribacter dumoffii is a Gram-negative bacterium that has been isolated from various environmental sources, including water and soil. While its clinical significance is not as well-established as that of more common pathogens, it has been associated with certain infections in immunocompromised patients. Clinical implications of F. dumoffii include its potential role in opportunistic infections, particularly in individuals with weakened immune systems, such as those undergoing chemotherapy or with chronic illnesses. The organism's pathogenicity may be linked to its ability to form biofilms, which can enhance its survival in hostile environments and contribute to immune evasion strategies. This characteristic can complicate treatment options, as biofilm-associated bacteria are often more resistant to antimicrobial agents. Currently, there is limited information regarding the antimicrobial resistance patterns of F. dumoffii, but like many Gram-negative bacteria, it may possess intrinsic resistance mechanisms that could pose challenges in clinical settings. In terms of medical applications, there is no documented use of F. dumoffii in probiotics, vaccines, or therapeutics. However, its presence in clinical specimens warrants further investigation to better understand its role in human health and disease. Overall, while F. dumoffii is not a common pathogen, its potential to cause infections in vulnerable populations highlights the need for continued research into its clinical relevance.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Fluoribacter dumoffii is a bacterium commonly associated with marine environments, particularly in coastal waters and sediments. This microorganism thrives in brackish waters and is often found in areas with high organic matter, such as mangroves and estuaries. Its ability to metabolize a variety of organic compounds allows it to play a significant role in the biogeochemical cycling of nutrients, particularly in the breakdown of complex organic materials. In these marine ecosystems, F. dumoffii contributes to the decomposition process, facilitating nutrient release back into the environment, which is essential for the growth of other organisms. This bacterium is also known to engage in symbiotic relationships with other marine microorganisms, enhancing the overall productivity of the ecosystem. Furthermore, F. dumoffii exhibits remarkable environmental adaptability, allowing it to survive in varying salinity levels and temperatures, which is crucial for its persistence in dynamic coastal habitats. Its presence is often indicative of healthy marine ecosystems, making it an important organism for ecological monitoring and research.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Fluoribacter dumoffii has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to thrive in environments with high levels of pollutants, making it a candidate for biodegradation processes. For instance, Fluoribacter dumoffii can be utilized in the treatment of wastewater, where it aids in the breakdown of organic compounds, thus contributing to the purification of water resources. In the realm of biofuel production, Fluoribacter dumoffii may play a role in the fermentation of biomass, converting organic materials into bioethanol or other biofuels. This process not only helps in energy production but also promotes the recycling of waste materials, aligning with sustainable practices. Moreover, the enzymatic activity of Fluoribacter dumoffii can be harnessed in pharmaceutical development, where specific enzymes produced by this microorganism could be used in the synthesis of pharmaceutical compounds or as biocatalysts in various chemical reactions. The ability of Fluoribacter dumoffii to produce unique enzymes makes it a valuable asset in the development of new drugs and therapeutic agents. Overall, the diverse capabilities of Fluoribacter dumoffii in biodegradation, fermentation, and enzyme production highlight its significance in advancing industrial processes and promoting environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	google/gemini-pro	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro
Motility	N/A	false	true	true	true	true	true	false	true	true	true	true	true	true	false	false	false	false	true	true	true	true	false	false	true	true	false	false
Gram staining	gram stain negative	gram stain variable ✗	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain positive ✗	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	aerotolerant ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Animal pathogenicity	TRUE	false ✗	true ✓	false ✗	true ✓	false ✗	true ✓	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗
Health association	N/A	true	true	false	true	true	true	false	false	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	false	false	true	true
Host association	FALSE	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	N/A	false	false	false	false	false	true	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Spore formation	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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