Prevotella histicola

General Information

Prevotella histicola is a fascinating microorganism that has garnered significant interest in recent years due to its unique characteristics and potential implications for human health. This bacterium is part of the Prevotella genus, which is known for its diverse metabolic capabilities and its role in the human microbiome, particularly within the oral and gut environments. One of the most intriguing aspects of P. histicola is its association with the human oral cavity and its potential link to various oral and systemic diseases. Research has suggested that P. histicola may play a role in the development of periodontal disease, a common inflammatory condition affecting the tissues surrounding the teeth. This makes it a valuable target for studies aiming to understand the microbial dynamics of oral health and disease. Additionally, P. histicola has been identified in the gastrointestinal tract, where it may contribute to the complex interplay of microbial communities that influence digestive health and immune function. Its presence in both the oral and gut microbiomes highlights its adaptability and the potential for cross-environmental interactions that could impact overall health. From a metabolic perspective, P. histicola is known for its ability to break down complex carbohydrates, which is a characteristic feature of many Prevotella species. This capability is particularly important in the context of the human diet, as it suggests that P. histicola may play a role in the digestion of dietary fibers and the production of short-chain fatty acids, which are beneficial for gut health. Moreover, the study of P. histicola has implications for understanding the balance of microbial communities and their impact on health and disease. Its interactions with other microorganisms and the host immune system are areas of active research, with the potential to uncover new insights into microbial ecology and the development of novel therapeutic strategies. In summary, Prevotella histicola is a microorganism of significant interest due to its role in human health, its metabolic versatility, and its potential implications for disease research. Its presence in both the oral and gut microbiomes underscores its importance in the study of microbial communities and their impact on human well-being.

Prevotella histicola is a fascinating anaerobic bacterium that is part of the diverse genus Prevotella, which is known for its role in the human microbiome. This species is particularly interesting due to its association with the gastrointestinal tract and its potential implications in human health. Prevotella histicola has been identified as a key player in the fermentation of dietary fibers, contributing to the production of short-chain fatty acids (SCFAs), which are vital for gut health and have anti-inflammatory properties. One of the unique aspects of Prevotella histicola is its ability to thrive in environments rich in complex carbohydrates, which makes it a valuable organism for studying the interactions between diet, gut microbiota, and overall health. Research has shown that this species may be involved in the modulation of immune responses, highlighting its potential role in maintaining gut homeostasis and influencing systemic health. Furthermore, Prevotella histicola has garnered attention in studies related to dysbiosis, a condition characterized by an imbalance in the gut microbiome that can lead to various diseases. Understanding the functions and mechanisms of Prevotella histicola could provide insights into therapeutic strategies for conditions such as inflammatory bowel disease (IBD) and metabolic disorders. In summary, Prevotella histicola stands out not only for its ecological role in the gut but also for its potential implications in health and disease, making it a significant subject of research in microbiology and nutrition.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacteroidota

Class: Bacteroidia

Order: Bacteroidales

Family: Prevotellaceae

Genus: Prevotella

Species: Prevotella histicola

NCBI ID

470565

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/018/128/125/GCA_018128125.1_ASM1812812v1

File for sequence-based predictions:
GCA_018128125.1_ASM1812812v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Prevotella histicola is a member of the human gut microbiota and has been associated with various clinical implications. It plays a role in maintaining gut health and is involved in the fermentation of dietary fibers, contributing to the production of short-chain fatty acids, which are beneficial for intestinal health. However, its presence has also been linked to certain diseases, particularly in individuals with compromised immune systems or underlying health conditions. Pathogenicity: Prevotella histicola has been implicated in infections such as periodontitis and other oral diseases. Its ability to form biofilms and interact with other pathogenic bacteria can exacerbate these conditions. Additionally, it has been found in cases of bacteremia and abscesses, indicating its potential to cause systemic infections under certain circumstances. Antimicrobial Resistance: There is emerging evidence that some strains of Prevotella histicola may exhibit antimicrobial resistance, complicating treatment options for infections associated with this organism. This resistance can be attributed to the organism's genetic adaptability and its ability to acquire resistance genes from other bacteria in the gut microbiome. Immune Evasion Strategies: Prevotella histicola employs various strategies to evade the immune response, including the production of polysaccharide capsules that inhibit phagocytosis and modulate host immune signaling pathways. This ability to evade detection and destruction by the immune system can contribute to its persistence in the human body and its role in chronic infections. Medical Applications: While Prevotella histicola is primarily studied for its pathogenic potential, it is also being explored for its role in probiotics and therapeutics. Some studies suggest that certain strains may have beneficial effects on gut health and could be used to restore microbial balance in dysbiosis. However, further research is needed to fully understand its therapeutic potential and safety in clinical applications. In summary, Prevotella histicola is a significant organism within the human microbiome, with both beneficial and harmful implications for human health, particularly in the context of infections, immune response, and antimicrobial resistance.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Prevotella histicola is a species of bacteria commonly found in the gastrointestinal tract of various mammals, including humans. This microorganism thrives in the anaerobic environments of the gut, where it plays a crucial role in the digestion of complex carbohydrates and the fermentation of dietary fibers. Its presence is particularly notable in the large intestine, where it contributes to the overall microbial diversity and health of the gut microbiome. Ecological Niches: _Prevotella histicola occupies a specific niche within the gut microbiome, often associated with a diet rich in plant materials. It is known to interact synergistically with other gut bacteria, enhancing the breakdown of polysaccharides and producing short-chain fatty acids (SCFAs) that are beneficial for host health. These SCFAs serve as an energy source for colonocytes and play a role in maintaining gut integrity and immune function. Symbiotic Relationships: This bacterium is part of a complex community of microorganisms that engage in mutualistic relationships with their host. By aiding in digestion and nutrient absorption, _Prevotella histicola helps maintain a balanced gut environment, which is essential for overall health. In return, it receives nutrients and a stable habitat within the host's gut. Environmental Adaptations: _Prevotella histicola has adapted to thrive in the low-oxygen conditions of the gut, utilizing fermentation pathways to metabolize substrates. Its ability to survive in such environments highlights its evolutionary adaptations to the mammalian digestive system. Overall, _Prevotella histicola is a vital component of the gut microbiome, contributing to the health and functionality of its host's digestive system while exemplifying the intricate relationships that exist within microbial communities.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Prevotella histicola has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This anaerobic bacterium is primarily known for its role in the fermentation of complex carbohydrates, which can be harnessed in the production of biofuels. By breaking down plant materials, Prevotella histicola contributes to the generation of biogas, a renewable energy source that can be utilized for heating and electricity generation. In the realm of waste management, Prevotella histicola plays a significant role in the biodegradation of organic waste. Its ability to thrive in anaerobic conditions allows it to effectively decompose organic matter in landfills and wastewater treatment facilities, thereby reducing the environmental impact of waste accumulation. This process not only helps in waste reduction but also aids in nutrient recycling, making it beneficial for soil health. Moreover, there is emerging interest in the pharmaceutical development sector, where Prevotella histicola may contribute to the production of bioactive compounds. These compounds can have potential applications in the development of new drugs or therapeutic agents, particularly in the field of gut health and microbiome research. Overall, Prevotella histicola demonstrates significant promise in various industrial sectors through its involvement in fermentation, biodegradation, and potential bioactive compound production, making it a valuable microorganism for sustainable practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	anthropic/claude-3-haiku:beta	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	mistralai/mistral-7b-instruct	google/palm-2-chat-bison-32k	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemma-7b-it	google/gemma-7b-it	google/gemini-pro	google/gemini-pro
Motility	N/A	false	true	false	false	true	true	true	false	false	false	true	true	false	false	false	false	true	true	false	false	false	false	true	true	true	true
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	anaerobic	anaerobic ✓	N/A	N/A	anaerobic ✓	aerotolerant ✗	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	aerotolerant ✗	aerotolerant ✗	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Animal pathogenicity	N/A	false	true	true	true	true	true	false	false	false	false	false	false	true	true	true	true	false	false	false	false	true	true	true	true	true	true
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	true	true	false	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	alpha	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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