Bibersteinia trehalosi

General Information

Bibersteinia trehalosi is a bacterium that belongs to the family Pasteurellaceae. This microorganism is particularly interesting due to its role in veterinary medicine, especially in the context of respiratory diseases in ruminants. One of the most notable aspects of Bibersteinia trehalosi is its association with bovine respiratory disease complex (BRDC), a significant health issue in cattle that leads to substantial economic losses in the livestock industry. In addition to cattle, Bibersteinia trehalosi is also known to affect sheep and goats, where it can cause systemic infections and septicemia, particularly in young animals. This pathogen is often found in the upper respiratory tract of healthy animals, but under certain conditions, it can become pathogenic, leading to severe disease outbreaks. From a research perspective, Bibersteinia trehalosi is valuable for studying host-pathogen interactions, particularly how environmental stressors and co-infections with other respiratory pathogens can trigger its pathogenicity. The bacterium's ability to evade the host immune system and its mechanisms of virulence are key areas of interest. Understanding these mechanisms can help in developing better preventive and therapeutic strategies against infections caused by this microorganism. Moreover, Bibersteinia trehalosi has been studied for its genetic diversity and adaptability, which contribute to its survival and pathogenic potential in various hosts. The bacterium's genome provides insights into its metabolic capabilities and potential targets for antimicrobial therapy. In summary, Bibersteinia trehalosi is a significant pathogen in veterinary medicine, with unique characteristics that make it a valuable subject for research into respiratory diseases, host-pathogen interactions, and microbial genetics.

Bibersteinia trehalosi is a notable bacterium primarily recognized for its role as a pathogen in ruminants, particularly sheep and cattle. This organism is a member of the family Pasteurellaceae and is closely related to other significant pathogens such as Pasteurella multocida. One of the most interesting aspects of B. trehalosi is its association with respiratory diseases, particularly in young lambs, where it can lead to severe pneumonia and other systemic infections. This highlights its importance in veterinary medicine and animal husbandry, as outbreaks can have substantial economic impacts on livestock production. Another unique characteristic of B. trehalosi is its ability to utilize trehalose, a disaccharide composed of two glucose molecules, as a carbon source. This metabolic capability not only aids in its survival in various environments but also distinguishes it from other closely related species that may not share this trait. The utilization of trehalose is particularly interesting from a biochemical perspective, as it plays a role in stress responses and energy metabolism in bacteria. Research into B. trehalosi has also revealed its potential for antibiotic resistance, which poses challenges for treatment in affected animals. Understanding the mechanisms behind this resistance is crucial for developing effective therapeutic strategies. This aspect of the organism makes it a valuable subject for studies focused on antimicrobial resistance, which is a growing concern in both veterinary and human medicine. In summary, Bibersteinia trehalosi stands out due to its pathogenicity in livestock, unique metabolic capabilities, and implications for antibiotic resistance, making it a significant organism for ongoing research in microbiology and veterinary science.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Gammaproteobacteria

Order: Pasteurellales

Family: Pasteurellaceae

Genus: Bibersteinia

Species: Bibersteinia trehalosi

NCBI ID

47735

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/035/658/435/GCF_035658435.1_ASM3565843v1

File for sequence-based predictions:
GCF_035658435.1_ASM3565843v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Bibersteinia trehalosi is primarily known for its role as a pathogen in ruminants, particularly in sheep and cattle. It is associated with respiratory infections and meningitis, leading to significant economic losses in livestock industries. In humans, while it is not a common pathogen, there have been rare cases of infections reported, particularly in immunocompromised individuals. The organism is known to exhibit pathogenicity through its ability to evade the host's immune response, often utilizing strategies such as capsule formation and the production of virulence factors that inhibit phagocytosis. Furthermore, B. trehalosi has shown antimicrobial resistance to several common antibiotics, which complicates treatment options for infections it may cause. This resistance is particularly concerning in veterinary medicine, where the use of antibiotics can lead to the selection of resistant strains. In terms of medical applications, while B. trehalosi is not used as a probiotic or in vaccine development, understanding its pathogenic mechanisms and resistance patterns is crucial for developing effective control measures in livestock and preventing potential zoonotic transmission. Overall, the clinical implications of B. trehalosi highlight the importance of monitoring this organism in both veterinary and public health contexts.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Bibersteinia trehalosi has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This bacterium is known for its role in biodegradation, where it can break down complex organic materials, making it valuable in the treatment of waste products. Its ability to metabolize trehalose, a sugar that can be found in various substrates, highlights its potential in fermentation processes, which can be harnessed for the production of biofuels and other bioproducts. In the context of biofuel production, Bibersteinia trehalosi can be utilized to convert biomass into fermentable sugars, which can then be further processed into ethanol or other biofuels. This process not only contributes to renewable energy sources but also aids in reducing waste from agricultural and industrial sectors. Moreover, the enzymatic activity of Bibersteinia trehalosi can be explored for pharmaceutical development, particularly in the synthesis of compounds that require specific enzymatic reactions. The bacterium's unique metabolic pathways may lead to the discovery of novel enzymes that can be used in drug formulation or as biocatalysts in various chemical reactions. Overall, the applications of Bibersteinia trehalosi in biotechnology, waste management, and pharmaceutical development underscore its significance in advancing sustainable industrial practices and enhancing the efficiency of bioprocesses.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	openai/gpt-3.5-turbo-0125	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	perplexity/llama-3-sonar-small-32k-chat	microsoft/phi-3-mini-128k-instruct	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-pro	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	google/gemma-7b-it	openchat/openchat-7b	openchat/openchat-7b
Motility	N/A	true	false	false	true	true	true	false	true	true	true	false	false	false	true	true	false	false	false	false	false	false	true	true	true	true	false	false
Gram staining	gram stain negative	gram stain negative ✓	N/A	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain variable ✗	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain positive ✗	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	facultatively anaerobic ✗	aerotolerant ✗	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	false	true	true	true	false	true	true	false	false	false	false	true	true	false	false	true	true	true	true	false	false
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	false ✗	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Hemolysis	N/A	N/A	beta	beta	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	beta	beta	N/A	N/A	N/A	N/A	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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