Streptomyces filamentosus

General Information

Streptomyces filamentosus is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. filamentosus is its ability to produce a wide array of antibiotics and bioactive compounds. This makes it an invaluable resource in the field of pharmaceutical research and biotechnology. Streptomyces species are known for their complex life cycle, which includes the formation of a mycelium and spore chains, contributing to their unique filamentous structure. This filamentous nature is not only a defining morphological trait but also plays a crucial role in their ability to colonize and decompose organic matter in soil environments. The production of secondary metabolites by S. filamentosus includes compounds with antibacterial, antifungal, and anticancer properties. These metabolites are synthesized through intricate biosynthetic pathways, making S. filamentosus a model organism for studying natural product biosynthesis. Researchers are particularly interested in the genetic and enzymatic mechanisms that underlie these pathways, as understanding them can lead to the discovery of new drugs and therapeutic agents. Moreover, S. filamentosus has been studied for its role in soil health and nutrient cycling. Its ability to degrade complex organic materials contributes to soil fertility and the breakdown of plant residues, highlighting its ecological importance. In summary, Streptomyces filamentosus is a microorganism of significant interest due to its prolific production of bioactive compounds, its complex life cycle, and its ecological role in soil environments. These characteristics make it a valuable subject for research in multiple scientific disciplines, including microbiology, biochemistry, and environmental science.

Streptomyces filamentosus is a fascinating actinobacterium known for its filamentous growth and ability to produce a wide array of bioactive compounds. This organism is particularly interesting due to its role in natural product biosynthesis, making it a valuable resource in pharmaceutical research. The secondary metabolites produced by S. filamentosus include antibiotics, antifungals, and immunosuppressants, which have significant implications for drug development and therapeutic applications. One of the unique characteristics of S. filamentosus is its complex life cycle, which includes the formation of aerial hyphae and spores. This developmental process not only contributes to its ecological success in various environments but also enhances its ability to produce secondary metabolites. The genetic and biochemical pathways involved in the synthesis of these compounds are of great interest to researchers, as they can provide insights into the mechanisms of antibiotic resistance and the potential for discovering new drugs. Additionally, S. filamentosus has been studied for its ability to degrade complex organic materials, which positions it as a potential agent for bioremediation. Its enzymatic capabilities allow it to break down pollutants, making it a candidate for environmental cleanup efforts. The exploration of its metabolic pathways could lead to innovative strategies for waste management and sustainable practices. Overall, Streptomyces filamentosus stands out as a model organism in microbiology, with its contributions to both medicine and environmental science.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces filamentosus

NCBI ID

67294

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/023/716/005/GCA_023716005.1_ASM2371600v1

File for sequence-based predictions:
GCA_023716005.1_ASM2371600v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces filamentosus is a filamentous bacterium known for its significant role in the production of antibiotics, particularly streptomycin. This antibiotic is crucial in the treatment of tuberculosis and other bacterial infections, highlighting the organism's importance in human health and therapeutics. Beyond its antibiotic production, Streptomyces filamentosus has been studied for its potential in biocontrol and agricultural applications, as it can suppress plant pathogens, thus contributing to sustainable agriculture practices. In terms of pathogenicity, Streptomyces filamentosus is generally considered non-pathogenic to humans; however, its close relatives within the genus can be opportunistic pathogens, particularly in immunocompromised individuals. This underscores the need for further research into the immune response elicited by this organism and its relatives. Moreover, the emergence of antimicrobial resistance is a growing concern, and while Streptomyces filamentosus itself is a source of antibiotics, the potential for resistance development in bacteria treated with its derivatives is an area of active investigation. Understanding the mechanisms of resistance and the genetic basis for antibiotic production in this organism could lead to novel therapeutic strategies. Overall, Streptomyces filamentosus serves as a vital organism in both clinical and agricultural contexts, with ongoing research aimed at harnessing its capabilities while monitoring for any potential risks associated with its use.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces filamentosus is a filamentous bacterium commonly found in soil and decaying organic matter. This microorganism thrives in a variety of terrestrial ecosystems, particularly in nutrient-rich environments where organic decomposition occurs. Its presence is often associated with the rhizosphere, the region of soil influenced by plant roots, where it plays a crucial role in nutrient cycling and soil health. In these soil ecosystems, Streptomyces filamentosus contributes to the breakdown of complex organic materials, aiding in the release of essential nutrients such as nitrogen and phosphorus. This process not only supports plant growth but also enhances soil structure and fertility. The bacterium is known for its ability to produce a wide range of bioactive compounds, including antibiotics, which can inhibit the growth of competing microorganisms, thus establishing a competitive advantage in its habitat. Additionally, Streptomyces filamentosus exhibits notable interactions with plants, often engaging in mutualistic relationships. These interactions can enhance plant resistance to pathogens and improve overall plant health, demonstrating the organism's significant role in agricultural ecosystems. Overall, the ecological niche of Streptomyces filamentosus is characterized by its adaptability to various soil types and its essential contributions to nutrient cycling, plant health, and microbial diversity within its habitats.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces filamentosus is renowned for its significant contributions to various industrial applications. One of the most notable areas is in pharmaceutical development, where Streptomyces filamentosus is a source of bioactive compounds, particularly antibiotics. This organism is known for its ability to produce antibiotics such as streptomycin, which is crucial in treating bacterial infections. The process of fermentation is utilized to cultivate this microorganism, allowing for the extraction and purification of these valuable compounds. In addition to its pharmaceutical applications, Streptomyces filamentosus plays a role in biotechnology through its enzymatic activities. It produces a variety of enzymes that can be harnessed for industrial processes, including those involved in the degradation of complex organic materials. This capability is particularly useful in waste management, where the organism can assist in the biodegradation of pollutants and organic waste, contributing to more sustainable waste treatment solutions. Furthermore, the potential of Streptomyces filamentosus in biofuel production is being explored, as its metabolic pathways can be utilized to convert biomass into biofuels. The organism's ability to break down lignocellulosic materials through its enzymatic activity can enhance the efficiency of biofuel production processes. Overall, Streptomyces filamentosus demonstrates a multifaceted utility across various industries, particularly in fermentation, biodegradation, and enzyme production, making it a valuable microorganism in the quest for sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	google/gemini-flash-1.5	google/gemini-pro	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct
Motility	N/A	false	false	false	false	false	true	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerotolerant ✗	N/A	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	false	false	true	true	true	false	true	false	false	false	false	true	true	false	false	false	false	true	true	true	true	true	true	false	false
Host association	FALSE	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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