Streptomyces violaceusniger

General Information

Streptomyces violaceusniger is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most striking features of S. violaceusniger is its ability to produce a variety of bioactive compounds, including antibiotics, antifungals, and antitumor agents. This makes it an invaluable resource in pharmaceutical research and biotechnology. Streptomyces species are known for their complex life cycle, which includes the formation of a mycelium and spore chains, contributing to their adaptability and survival in diverse environments. S. violaceusniger is particularly noted for its production of melanin-like pigments, which not only give it a distinctive dark coloration but also provide protection against environmental stresses such as UV radiation and oxidative damage. The genome of S. violaceusniger is of significant interest to researchers due to its large size and the presence of numerous gene clusters responsible for the biosynthesis of secondary metabolites. This genetic wealth offers a treasure trove of potential new drugs and industrial enzymes. Moreover, S. violaceusniger has been studied for its role in soil health and nutrient cycling, as it can decompose complex organic materials, contributing to the fertility and structure of the soil. Its interactions with plant roots also suggest potential applications in agriculture, such as promoting plant growth and protecting against pathogens. In summary, Streptomyces violaceusniger is a microorganism of great interest due to its diverse metabolic capabilities, potential for novel drug discovery, and ecological importance. Its unique characteristics make it a valuable subject for ongoing research in multiple scientific fields.

Streptomyces violaceusniger is a fascinating actinobacterium known for its remarkable ability to produce a wide array of bioactive compounds, including antibiotics and other secondary metabolites. This organism is particularly notable for its production of violacein, a pigment with significant antimicrobial and anticancer properties, which has garnered interest in pharmaceutical research. The unique metabolic pathways of S. violaceusniger allow it to synthesize various compounds that can be harnessed for therapeutic applications, making it a valuable resource in drug discovery and development. One of the most interesting aspects of S. violaceusniger is its ecological role in soil environments, where it contributes to the decomposition of organic matter and the cycling of nutrients. This actinobacterium is also known for its ability to produce enzymes that can degrade complex polysaccharides, which is of great interest in biotechnology, particularly in the development of bioprocesses for waste management and biofuel production. Furthermore, S. violaceusniger has been studied for its potential in biocontrol, as it can inhibit the growth of various plant pathogens, thus offering a natural alternative to chemical pesticides. Its genetic tractability allows researchers to manipulate its biosynthetic pathways, leading to the discovery of novel compounds with potential applications in medicine and agriculture. Overall, Streptomyces violaceusniger stands out as a model organism in the field of natural product research, with implications that extend into environmental sustainability and health sciences.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces violaceusniger

NCBI ID

68280

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/509/775/GCF_001509775.1_ASM150977v1

File for sequence-based predictions:
GCF_001509775.1_ASM150977v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces violaceusniger is a filamentous bacterium known for its significant role in the production of various bioactive compounds, particularly antibiotics. It is primarily recognized for its ability to produce violacein, a pigment with potential antimicrobial and antitumor properties. This compound has been studied for its effectiveness against a range of pathogens, making S. violaceusniger a valuable organism in the field of pharmaceutical microbiology. In terms of pathogenicity, S. violaceusniger is generally considered non-pathogenic to humans; however, its close relatives within the genus Streptomyces can sometimes be associated with opportunistic infections, particularly in immunocompromised individuals. The organism's ability to produce a variety of secondary metabolites has led to its investigation in the context of antimicrobial resistance, as some of its derivatives may offer new avenues for combating resistant strains of bacteria. Moreover, the potential use of S. violaceusniger in probiotics and therapeutics is being explored, particularly in the context of gut health and the modulation of the human microbiome. Its metabolites may play a role in enhancing the immune response or providing protective effects against certain diseases. Overall, while Streptomyces violaceusniger is not directly associated with human disease, its contributions to antibiotic production and potential therapeutic applications underscore its importance in medical microbiology and the ongoing fight against infectious diseases.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces violaceusniger is a filamentous bacterium commonly found in soil and decaying organic matter, particularly in tropical and subtropical regions. This microorganism thrives in nutrient-rich environments where it plays a crucial role in the decomposition of organic materials, contributing to nutrient cycling within the ecosystem. Its ability to produce a wide array of bioactive compounds, including antibiotics, makes it a significant player in the microbial community of these habitats. In the soil biome, S. violaceusniger interacts with various other microorganisms, forming complex relationships that can include mutualism and competition. For instance, it may engage in symbiotic relationships with plants, promoting plant health through the production of growth-promoting substances. Additionally, its antibiotic production can inhibit the growth of pathogenic bacteria, thus maintaining a balanced microbial ecosystem. This organism is also known to adapt to varying environmental conditions, showcasing resilience in drought-prone or nutrient-poor soils. Its ability to form spores allows it to survive in harsh conditions, ensuring its persistence in the environment. Overall, Streptomyces violaceusniger is an essential component of the terrestrial biome, contributing to soil health and fertility while engaging in intricate ecological interactions.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces violaceusniger is renowned for its significant contributions to various industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and waste management. This actinobacterium is a prolific producer of secondary metabolites, including antibiotics such as violacein, which has been studied for its potential in treating infections and as an anti-cancer agent. In the realm of biotechnology, Streptomyces violaceusniger is utilized in the fermentation process to produce valuable bioactive compounds. Its ability to synthesize a wide range of enzymes makes it a key player in the production of biocatalysts for various industrial processes, including the degradation of complex organic materials. In waste management, this microorganism has demonstrated effective capabilities in biodegradation, particularly in the breakdown of pollutants and organic waste. Its enzymatic activity allows it to degrade complex compounds, making it useful in the treatment of contaminated environments. Moreover, Streptomyces violaceusniger has been explored for its potential in biofuel production. The organism's metabolic pathways can be harnessed to convert biomass into biofuels through fermentation processes, contributing to sustainable energy solutions. Overall, the versatility of Streptomyces violaceusniger in producing enzymes, antibiotics, and its role in biodegradation positions it as a valuable asset in multiple industries, showcasing its importance in advancing both environmental and health-related applications.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	anthropic/claude-3.5-sonnet	meta-llama/llama-3-70b-instruct:nitro	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	N/A	false	false	false	false	false	true	false	true	false	false	false	false	true	true	false	false	false	false	false	false	false	false	true	true	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	true	false	true	true	true	true	false	false	false	false	false	true	true	true	true	false	false	true	true	true	true	true	true	true	true	false	false
Host association	FALSE	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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