Streptomyces chiangmaiensis

General Information

Streptomyces chiangmaiensis is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. chiangmaiensis is its ability to produce a wide array of bioactive compounds, including antibiotics, antifungals, and antitumor agents. This makes it a valuable subject of study in pharmaceutical research and biotechnology. Streptomyces species are known for their complex life cycle and filamentous growth, which resembles that of fungi. This unique growth pattern allows them to thrive in diverse environments, particularly in soil where they play a crucial role in decomposing organic matter and recycling nutrients. The production of secondary metabolites by S. chiangmaiensis is of particular interest because these compounds have potential therapeutic applications. For instance, the antibiotics produced by this species can be effective against a range of pathogenic bacteria, making it a potential source of new antimicrobial agents in the fight against antibiotic-resistant infections. Moreover, S. chiangmaiensis has been studied for its potential in bioremediation. Its ability to degrade complex organic pollutants highlights its environmental significance. This capability can be harnessed to clean up contaminated sites, contributing to environmental sustainability. In summary, Streptomyces chiangmaiensis is a microorganism of significant interest due to its prolific production of bioactive compounds, its unique filamentous growth, and its potential applications in both medicine and environmental science. Its study not only advances our understanding of microbial ecology and secondary metabolism but also opens up new avenues for the development of novel therapeutic and environmental solutions.

Streptomyces chiangmaiensis is a fascinating actinobacterium that was first isolated from soil samples in Chiang Mai, Thailand. This organism is particularly notable for its ability to produce a diverse array of bioactive compounds, which makes it a valuable resource in pharmaceutical research. Among its metabolites, S. chiangmaiensis has been shown to produce various antibiotics, including those effective against resistant strains of bacteria, highlighting its potential in the ongoing battle against antibiotic resistance. One of the unique aspects of S. chiangmaiensis is its genetic capacity for secondary metabolite production. The genome of this species contains numerous biosynthetic gene clusters, which are responsible for the synthesis of these bioactive compounds. This genetic diversity not only contributes to its ecological role in soil but also positions it as a promising candidate for biotechnological applications. Furthermore, S. chiangmaiensis has been studied for its antifungal properties, making it an interesting subject for research in agricultural applications, particularly in developing natural fungicides. Its ability to thrive in specific environmental conditions also provides insights into microbial adaptation and survival strategies in diverse ecosystems. Overall, the unique metabolic capabilities and ecological significance of Streptomyces chiangmaiensis underscore its potential as a source of novel compounds for drug development and agricultural innovation, making it a valuable organism in both microbiological and biotechnological research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces chiangmaiensis

NCBI ID

766497

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/036/281/785/GCF_036281785.1_ASM3628178v1

File for sequence-based predictions:
GCF_036281785.1_ASM3628178v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces chiangmaiensis is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. This particular species has been studied for its potential in antimicrobial resistance and its ability to produce novel antibiotics that may be effective against resistant strains of bacteria. Clinical implications of Streptomyces chiangmaiensis include its potential use in the development of new therapeutic agents, particularly in the context of increasing antibiotic resistance in pathogenic bacteria. In addition to its therapeutic potential, Streptomyces chiangmaiensis has been investigated for its role in human health through its production of secondary metabolites that may have beneficial effects on the human microbiome. Some studies suggest that certain strains of Streptomyces can act as probiotics, contributing to gut health and potentially modulating the immune response. However, the pathogenicity of Streptomyces chiangmaiensis is not well-documented, and it is not typically associated with infections in humans. Its primary relevance lies in its biotechnological applications rather than direct clinical disease associations. Further research is needed to fully understand its interactions with the human body and any potential implications for immune evasion or disease associations.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces chiangmaiensis is a species of actinobacteria that is primarily found in soil ecosystems and decaying organic matter. This microorganism thrives in environments rich in organic material, where it plays a crucial role in the decomposition process. Its ability to break down complex organic compounds contributes significantly to nutrient cycling within these biomes. Soil Biomes: In soil, Streptomyces chiangmaiensis is often associated with the rhizosphere, the region of soil that is directly influenced by root secretions and associated soil microorganisms. Here, it engages in nutrient exchange and can promote plant health through the production of bioactive compounds that inhibit pathogenic fungi and bacteria. This interaction exemplifies a form of symbiosis, where the bacteria benefit from the organic compounds released by plants, while the plants benefit from the protective effects of the bacteria. Decaying Organic Matter: In environments characterized by decaying plant material, Streptomyces chiangmaiensis contributes to the breakdown of cellulose and lignin, essential processes in the decomposition of plant matter. This activity not only aids in the recycling of nutrients back into the soil but also supports the overall health of the ecosystem by maintaining soil structure and fertility. Overall, Streptomyces chiangmaiensis is an integral component of its native biomes, showcasing its importance in ecological balance and sustainability through its roles in decomposition, nutrient cycling, and plant-microbe interactions.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces chiangmaiensis has shown significant potential in various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This actinobacterium is known for its ability to produce a wide range of bioactive compounds, including antibiotics, which are crucial in the fight against bacterial infections. The production of these compounds often involves fermentation processes, where the organism is cultivated under specific conditions to maximize yield. In addition to its pharmaceutical applications, Streptomyces chiangmaiensis has demonstrated capabilities in waste management. It can effectively degrade complex organic materials, making it a valuable asset in biodegradation processes. This characteristic is particularly useful in the treatment of agricultural waste and other organic pollutants, contributing to more sustainable waste management practices. Furthermore, the enzymatic activities of Streptomyces chiangmaiensis are noteworthy, as it can produce various enzymes that facilitate the breakdown of lignocellulosic biomass. This property is essential for biofuel production, where the conversion of plant materials into fermentable sugars is a critical step. The organism's enzymes can enhance the efficiency of enzyme production processes, leading to improved yields of biofuels. Overall, Streptomyces chiangmaiensis represents a versatile microorganism with promising applications in biotechnology, waste management, and biofuel production, showcasing its importance in advancing industrial processes and sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/gemini-flash-1.5	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemma-7b-it	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro
Motility	N/A	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false
Gram staining	gram stain positive	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	false	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	false	false	true	true	true	true	true	false	false	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	spirillum ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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