Bartonella tribocorum

General Information

Bartonella tribocorum is a fascinating bacterium that belongs to the genus Bartonella, which is known for its ability to infect a wide range of mammalian hosts, including humans. One of the most intriguing aspects of B. tribocorum is its role as a model organism for studying the pathogenesis of Bartonella infections. This species has been extensively used in research to understand the mechanisms of bacterial persistence and immune evasion. Key Characteristics: - Host Interaction: B. tribocorum is particularly interesting due to its ability to infect and persist in the bloodstream of its mammalian hosts. This persistence is facilitated by its unique strategies to evade the host immune system, making it a valuable model for studying chronic infections. - Virulence Factors: The bacterium possesses a variety of virulence factors, including a type IV secretion system, which is crucial for the delivery of effector proteins into host cells. These effector proteins manipulate host cell functions to the bacterium's advantage, promoting intracellular survival and replication. - Genomic Insights: The genome of B. tribocorum has been sequenced, providing valuable insights into the genetic basis of its pathogenicity. Comparative genomics with other Bartonella species has revealed conserved and unique genes that contribute to its ability to cause disease. - Research Applications: Due to its well-characterized infection model in rodents, B. tribocorum is widely used in experimental studies to investigate the dynamics of Bartonella infections, including the host immune response and the development of potential therapeutic interventions. Unique Features: - Intracellular Lifestyle: B. tribocorum has a remarkable ability to invade and survive within endothelial cells, which line the interior surface of blood vessels. This intracellular lifestyle is a hallmark of the Bartonella genus and is critical for its pathogenicity. - Vector Transmission: Like other Bartonella species, B. tribocorum is transmitted by arthropod vectors, such as fleas. This vector-borne transmission is an important aspect of its epidemiology and contributes to its spread among mammalian hosts. In summary, Bartonella tribocorum is a valuable organism for scientific research due to its unique pathogenic mechanisms, its ability to persist in host organisms, and its use as a model for studying Bartonella infections. Its genomic and virulence characteristics make it a key subject in the field of infectious disease research.

Bartonella tribocorum is a fascinating bacterium that belongs to the genus Bartonella, which is known for its association with various animal and human diseases. This particular species was first identified in the blood of a rodent, specifically the common rat, and has since been recognized for its potential role in zoonotic infections. What makes Bartonella tribocorum particularly interesting is its ability to persist in the bloodstream of its hosts, which can lead to chronic infections. One of the unique aspects of Bartonella tribocorum is its genetic diversity, which can provide insights into the evolutionary adaptations of the Bartonella genus. Research into this species can enhance our understanding of host-pathogen interactions, especially in the context of rodent reservoirs. The bacterium has been implicated in various pathologies, although its clinical significance in humans is still being explored. Furthermore, Bartonella tribocorum is of interest in the field of vector biology, as it is transmitted by ectoparasites such as fleas and ticks. Studying its transmission dynamics can shed light on the ecology of vector-borne diseases and the role of wildlife in maintaining these pathogens. This makes Bartonella tribocorum a valuable subject for research in both microbiology and epidemiology, particularly in understanding how environmental factors influence the spread of infectious diseases.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Alphaproteobacteria

Order: Hyphomicrobiales

Family: Bartonellaceae

Genus: Bartonella

Species: Bartonella tribocorum

NCBI ID

85701

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/000/689/355/GCA_000689355.1_PRJEB5999_assembly_1

File for sequence-based predictions:
GCA_000689355.1_PRJEB5999_assembly_1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Bartonella tribocorum is a member of the genus Bartonella, which is known for its association with various infections in humans and animals. While B. tribocorum is less studied compared to other species like Bartonella henselae, it has been implicated in certain clinical conditions, particularly in immunocompromised patients. Clinical relevance includes its potential role in causing bacteremia and endocarditis, although these associations are not as well-documented as with other Bartonella species. One of the notable aspects of B. tribocorum is its ability to evade the immune response through various mechanisms, including the expression of surface proteins that help it avoid detection by host immune cells. This immune evasion can lead to chronic infections that are difficult to diagnose and treat. In terms of antimicrobial resistance, there is limited data available, but like other members of the genus, B. tribocorum may exhibit resistance to certain antibiotics, complicating treatment options. This highlights the importance of accurate identification and susceptibility testing in clinical settings. While B. tribocorum is not commonly associated with outbreaks, its presence in animal reservoirs suggests a potential for zoonotic transmission, which could pose risks to human health, particularly in those with weakened immune systems. Further research is needed to fully understand its pathogenic potential and the implications for public health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Bartonella tribocorum is a bacterium primarily associated with the domestic cat and is often found in environments where these animals thrive. This organism is typically located in urban and suburban ecosystems where cats are prevalent, such as residential areas, parks, and gardens. Its presence is closely linked to the fecal matter and saliva of infected animals, which can contaminate soil and water sources, creating a niche for the bacterium to persist. In terms of ecological interactions, Bartonella tribocorum plays a significant role in the microbial community associated with feline hosts. It is known to engage in symbiotic relationships with its hosts, potentially influencing the health and immune responses of the cats. This bacterium can also be transmitted to humans, highlighting its role in zoonotic transmission and the importance of understanding its ecological dynamics. The adaptability of Bartonella tribocorum to various environmental conditions, including its ability to survive in vector populations such as fleas, underscores its resilience and ecological significance. Its interactions with both hosts and vectors illustrate the complex relationships within these biomes, emphasizing the importance of monitoring and studying this organism in the context of urban wildlife and public health.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Bartonella tribocorum has garnered attention for its potential applications in various industrial sectors, particularly in biotechnology and pharmaceutical development. This organism is known for its role in pathogen detection and diagnostic applications, which can be crucial in the development of new diagnostic tools for vector-borne diseases. Its unique genetic and metabolic characteristics allow for the exploration of novel therapeutic targets, making it a candidate for drug development against diseases caused by related pathogens. In the realm of biotechnology, Bartonella tribocorum can be utilized in the study of host-pathogen interactions, which is essential for understanding disease mechanisms and developing effective treatments. The organism's ability to survive in various environments also opens avenues for research into biodegradation processes, although this is less documented compared to other microorganisms. While Bartonella tribocorum is not primarily known for applications in biofuel production or waste management, its study contributes to the broader understanding of microbial ecology and the potential for using similar organisms in these fields. Overall, the focus on Bartonella tribocorum lies predominantly in its pharmaceutical and biotechnological applications, particularly in the context of disease research and diagnostics.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	google/gemini-pro	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	openai/gpt-4o	openai/gpt-4o	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	google/gemma-7b-it	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	N/A	false	true	false	false	false	false	true	true	false	false	true	true	false	false	false	false	false	false	true	true	true	true	false	false	false	false	true	true
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	N/A	facultatively anaerobic ✗	aerotolerant ✗	facultatively anaerobic ✗	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Animal pathogenicity	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biosafety level	N/A	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 3	biosafety level 3	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Hemolysis	N/A	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

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